Dr. Guo’s study focuses on the phage-host interactions, and have delved into the intricate mechanisms governing bacteriophage activities within microbial communities, particularly in biofilm environments. His recent research has involved in the critical role of filamentous bacteriophages (Pf) in biofilm formation and virulence in Pseudomonas aeruginosa. By studying the Pf4 and Pf6 prophages, he has uncovered novel functions of toxin-antitoxin (TA) systems encoded by these prophages, shedding light on their impact on phage production, defense against lytic phages, and phage genome dynamics, expanding our understanding of phage biology and its influence on microbial community dynamics within biofilms. His research has been published in Nature Communications, Cell Reports, Nucleic Acids Research, Environmental Microbiology, and Journal of Bacteriology.